Effect of shilajit on blood glucose and lipid profile in. Hypoglycemic and pancreatic protective effects of portulaca oleracea extract in alloxan induced diabetic rats basma k. Research article antidiabetic effect of sida cordata in. Alloxan monohydrate is used to induce diabetes mellitus in albino rats in the dose of 120mgkg i. Upon alloxan 150mgkg body weight induction, the diabetic animals showed marked increase in the values of plasma glucose, urea, uric acid, creatinine and concomitant decrease in. In alloxan induced diabetic rats, the body weight of the da extract treated animals had shown a significant increase p free radical. Antidiabetic activity of extract on alloxan induced diabetic rats. Antioxidant, antihyperglycemic, and antihyperlipidemic. Research article antidiabetic effect of sida cordata in alloxan induced diabetic rats naseeralishahandmuhammadrashidkhan department of biochemistry, faculty of.
Diabetes mellitus impairs glucose homeostasis causing neurological disorders due to perturbation in utilization of glucose. Pdf alloxaninduced diabetes, a common model for evaluating the. The present study investigates the preventive effect of fasting in alloxaninduced diabetic rats. Diabetic control rats were administered with 150mgkg of alloxan solution, standard pellets and water adlibitum for 21 days. The resulting displaced fracture in diabetic rats requires long periods for remodeling and complete bone consolidation. Pdf diabetes mellitus is affecting many in workforce, thus have a major impact on both individual and national productivity. In indias indigenous system of medicine, coriandrum sativum cs, commonly used as a food ingredient, is claimed to be useful for various ailments.
This is attributed to break down of adipose tissue lipids and skeletal muscle protein. Alloxan has been administered in single or multiple doses, through different routes intraperitoneal. Diabetic rats were given macerated preparation of allium sativum garlic at a dose of 6. Antidiabetic effect of hydroalcoholic extract of carthamus tinctorius l. Biochemical effects of hydroclathrus clathratus on alloxan. Antihyperglycemic and antihyperlipidemic effects of. The oxidative stress induced by alloxan arises due to a compromise in natural antioxidant mechanism and an increase in.
The hypolipidemic effect of leaf essential oil of citrus sinensis in alloxaninduced diabetic rats was evaluated. Three groups of 36 rats was induced diabetes with single ip administration of 5% wv of alloxan monohydrate in normal saline. Antidiabetic effect of sida cordata in alloxan induced diabetic rats. To study the effect of shilajit a herbomineral preparation on blood glucose and lipid profile in euglycemic and alloxaninduced diabetic rats and its effects on the above parameters in.
Effect of dme on alloxaninduced diabetic rats a total of twenty five 25 diabetic and five 5 normoglycemic rats of both sexes were used. Hypoglycemic and antioxidant effects of leaf essential oil. The aim of the present study was the evaluation of possible protective effects of quercetin and chrysin in experimental alloxaninduced diabetes in rats. Pdf antidiabetic activity of extract on alloxan induced diabetic rats.
Diabetes mellitus is among the most common disorder in developed and developing countries, and the disease is increasing rapidly in most parts of the world. Cystoseira myrica aqueous extract on alloxan induced diabetic rats. Forty albino rats 150200 g were randomly selected into 4 groups of 10 rats each, representing normal control, diabetic control, diabetic treated with 14. Sulaiman 6 1 department of pharmacology and therapeutics, faculty of medicine. Research article alloxan induced diabetes mellitus in. Aloe vera is used worldwide for several medical purposes as alternative medicine. Preventive effects of flavonoids on alloxaninduced. Biochemical and haematological effects of the leaf extract. Normal rats given blet 200 mgkg body weight in aqueous solution daily using an intragastric tube for 4 weeks. The present study was carried out to evaluate the antidiabetic activity of vinca rosea methanolic whole plant extracts in alloxan induced diabetic rats for 14 days. The extract did not produce hypoglycemic activity at both the dose levels in normal, fasted rats.
Alloxaninduced diabetes is a form of insulindependent diabetes mellitus that occurs as a result of alloxan administration or injection to animals. The elevated of blood glucose, free fatty acid and insulin resistance will cause the endothelial dysfunction, hemostasis disturbances that lead to. The study found that alloxaninduced diabetic rats exhibited significant % reduction in body weight. Comparison of streptozotocin and alloxaninduced diabetes. Extract in alloxan induced diabetic rats enas ali kamel mohamed lecturer in biochemistry and nutrition department womens college, ain shams university abstract. Alloxaninduced diabetes, a common model for evaluating. The methanolic whole plant extract at high dose 500 mgkg exhibited significant antihyperglycemic activity than whole plant extract at low dose 300 mgkg in diabetic rats. Histopathological assessment of the kidney of alloxan. Diabetes was induced by a single intraperitoneal injection of alloxan 150 mgkg b. Alloxaninduced and insulinresistant diabetes mellitus. Effect of aloe vera leaf extract on alloxan induced. Time course effect of alloxan on blood glucose level of rat.
Histopathological study of the liver of alloxan induced diabetic rats and macerated allium sativum garlic ameliorative effect. Cagle university of tennessee knoxville this thesis is brought to you for free and open access by the graduate school at trace. In spite of continuous new drug development to treat. The rats were divided into following 5 groups of 6 each after the induction of alloxan diabetes. Diabetes was induced in albino rat models with alloxan monohydrate 40 mgkg. Alloxaninduced diabetes, a common model for evaluating the. Antioxidant and hypoglycemic activity of strawberry fruit. Nigerian honey ameliorates hyperglycemia and dyslipidemia.
The mechanisms responsible for failure of glycaemic control in diabetes need to be thoroughly elucidated and hence the present study was initiated. Rats with blood glucose levels above 250 mgdl were considered diabetic 30 and selected for the study. The mechanism of alloxan and streptozotocin action in b. Effect of crude oil pollution on phytochemical and anti. Alloxaninduced insulin release is, however, of short duration and is followed by complete suppression of the islet response to glucose, even when high concentrations 16. Antidiabetic, hypolipidemic and histopathological analysis of. Effect of aloe vera leaf extract on alloxan induced diabetes in young mice j. To establish its utility in diabetes mellitus, the present study evaluated the antidiabetic and antioxidant effects of cs in alloxan. The present study investigated the antioxidant effects of three standard antidiabetic agents belonging to three different classes, metformin met, glibenclamide gli, and repaglinide rep, in alloxaninduced diabetic rats. Diabetes is usually accompanied by increased production of free radicals or. Hypoglycemic activity of cucumis sativus extract on. The effects of alloxan on the histology of the pancreas. Antidiabetic activity of ethanolic extract of tubers of.
The aim of the present study was the evaluation of possible protective effects of quercetin and chrysin in experimental alloxan induced diabetes in rats. Antidiabetic effect of artemisia absinthium extracts on. Department of zoology, sadguru gadage maharaj college, karad 415110, india available online. Samson oyebadejo, enoobong bassey, ajayi oyewunmi, victor archibong and ekaete usoro. The diabetic rats which showed blood glucose levels in. Histopathological study of the liver of alloxan induced. Alloxan has been shown to induce free radical production and cause tissue injury. Antihyperglycemic and antidyslipidemic activity of musa. The present study was aimed to evaluate the antidiabetic, antihyperlipidemic and antioxidative activity of. Antidiabetic effect of the egyptian honey bee apis. It has been estimated that up to onethird of patients with diabetes mellitus use some form. Alloxan has been administered in single or multiple doses, through different routes intraperitoneal, intravenous and subcutaneous. Effect of luff aegyptica leaf extract on body weigh in alloxan induced diabetic rats. Eighteen adult male wistar rats weighing 180 to 230 g were randomly divided into 3 equal groups including.
It has been successfully induced in a variety of animal species. Alloxaninduced diabetes delays repair in a rat model of. Alloxan induced insulin release is, however, of short duration and is followed by complete suppression of the islet response to glucose, even when high concentrations 16. The rats randomly selected were divided into six 6 groups of five 5 rats per group. This was confirmed through histological examination of the pancreas and liver of alloxan induced diabetic rats. Alloxaninduced diabetes is a form of insulin dependent diabetes mellitus that. Extract ethanol of poguntano in alloxan induced diabetic rats.
Alloxaninduced diabetes is a form of insulindependent diabetes mellitus that. The rats were randomly grouped into four as follows. In alloxaninduced diabetic rats, both the extracts decreased blood sugar. Allium sativum, alloxan, diabetes mellitus, histopathology, liver and weaning rats. The effects of alloxan on the histology of the pancreas, thyroid and adrenal glands of the white rat julien l. Alloxaninduced diabetic rats as described elsewhere 7, male wistar rats 190210 g body weight were injected with alloxan 110 mgkg through intraperitonial route. Honey treatment did not improve % change in body weight in diabetic rats.
Effect of shilajit on blood glucose and lipid profile in alloxaninduced diabetic rats n. Journal of chemical and pharmaceutical research, 2016, 84. Hypoglycaemic and antidiabetic activity of stem bark extracts. Hypoglycemic effects in alloxaninduced diabetic rats of the. The rats were divided into four groups as follows after the induction of alloxan. Absolute weight of testis, seminal vesicle and prostate gland in control, alloxan.
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